Louis PASTEUR

Autograph manuscript by Louis Pasteur. One page in black ink on a single leaf, with numerous erased words and crossed-out passages.

Unpublished note by Pasteur on his rabies vaccine.

Pasteur was under the scrutiny of countless of opponents, scientific as well as political, and bemoans the "attacks as violent as they were incomprehensible" he endured. The manuscript also announces the popular success of his vaccine, as subscriptions for his future Institute were in full swing.

First edition illustrated with two etched plates under tissue guards.

Claude Bernard’s (1813–1878) laboratory notes on alcoholic fermentation (see pp. 3–33) record his experiments on the search for yeast germs on grape clusters, the formation of alcohol in grape juice without ferment, on sound and rotten grapes, on the search for a soluble alcoholic ferment and the influence of decay, and on the production of alcohol. All these experiments were conducted on his estate at Saint-Julien in October 1877, during the grape harvest.

This conception of a soluble ferment as the origin of yeast, a living organism, marked the starting point of the famous controversy between Pasteur and Berthelot.

Rare and appealing copy, largely uncut.

First edition of this major work, illustrated with 12 engraved plates and 85 figures in the text (cf. Garrison-Morton 2485. Osler 1550. Duveen 461. Cushing P/139. Waller 10966. Norman 1658).

In studying the process of fermentation, Pasteur demonstrated that the spoilage of beer was caused by airborne microorganisms, and not by spontaneous generation as previously believed.

His research contributed significantly to the treatment and preservation of perishable beverages such as beer, wine, and milk.

A very attractive copy, preserved in its original wrappers.